Randomized trial evaluating self-sampling for HPV DNA based tests for cervical cancer screening in Nigeria
Identifieur interne : 000323 ( Main/Exploration ); précédent : 000322; suivant : 000324Randomized trial evaluating self-sampling for HPV DNA based tests for cervical cancer screening in Nigeria
Auteurs : Fatima Modibbo [Nigeria] ; K. C. Iregbu [Nigeria] ; James Okuma [Nigeria] ; Annemiek Leeman [Pays-Bas] ; Annemieke Kasius [Pays-Bas] ; Maurits De Koning [Pays-Bas] ; Wim Quint [Pays-Bas] ; Clement Adebamowo [États-Unis]Source :
- Infectious Agents and Cancer [ 1750-9378 ] ; 2017.
Abstract
Cervical cancer incidence and mortality rates in Sub-Saharan Africa (SSA) remain high due to several factors including low levels of uptake of cervical cancer screening. Self-collection of cervicovaginal samples for HPV DNA testing may be an effective modality that can increase uptake of cervical cancer screening in SSA and hard to reach populations in developed countries. We investigated whether self-collection of cervicovaginal samples for HPV DNA tests would be associated with increased uptake of screening compared with clinic based collection of samples. Furthermore, we compared the quality of samples collected by both approaches for use in HPV genotyping.
We conducted a community based randomized trial in a semi-urban district of Abuja, Nigeria with 400 women, aged 30 to 65 years randomized to either hospital-collection or self-collection of cervicovaginal samples. We compared cervical cancer screening uptake among the 2 groups and evaluated the concentration of human DNA in the samples by measuring RNase P gene levels using qPCR. High-risk HPV DNA detection and typing was done using the GP5+/6+ Luminex system.
Most participants in the self-collection arm (93%, 185/200) submitted their samples while only 56% (113/200) of those invited to the hospital for sample collection attended and were screened during the study period (
Our study shows that self-sampling significantly increased uptake of HPV DNA based test for cervical cancer screening in this population and the samples collected were adequate for HPV detection and genotyping. Cervical cancer screening programs that incorporate self-sampling and HPV DNA tests are feasible and may significantly improve uptake of cervical cancer screening in SSA.
Url:
DOI: 10.1186/s13027-017-0123-z
PubMed: 28184239
PubMed Central: 5294803
Affiliations:
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institution-id-type="GRID">grid.411024.2</institution-id><institution>Department of Epidemiology and Public Health,</institution><institution>University of Maryland School of Medicine,</institution></institution-wrap>Baltimore, MD USA</nlm:aff><country>États-Unis</country><placeName><region type="state">Maryland</region></placeName><wicri:cityArea>Baltimore</wicri:cityArea></affiliation><affiliation wicri:level="2"><nlm:aff id="Aff5"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2175 4264</institution-id><institution-id institution-id-type="GRID">grid.411024.2</institution-id><institution>Institute of Human Virology and Greenebaum Comprehensive Cancer Centre,</institution><institution>University of Maryland School of Medicine,</institution></institution-wrap>Baltimore, MD USA</nlm:aff><country>États-Unis</country><placeName><region 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xml:lang="fr">Nigeria</country><wicri:regionArea>Plot 132 Central Business District (Phase II), PMB 425 Garki, Abuja</wicri:regionArea><wicri:noRegion>Abuja</wicri:noRegion></affiliation></author><author><name sortKey="Iregbu, K C" sort="Iregbu, K C" uniqKey="Iregbu K" first="K. C." last="Iregbu">K. C. Iregbu</name><affiliation wicri:level="1"><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 0647 037X</institution-id><institution-id institution-id-type="GRID">grid.416685.8</institution-id><institution></institution><institution>Department of Medical Microbiology and Parasitology, National Hospital Abuja,</institution></institution-wrap>Plot 132 Central Business District (Phase II), PMB 425 Garki, Abuja, 90001 Nigeria</nlm:aff><country xml:lang="fr">Nigeria</country><wicri:regionArea>Plot 132 Central Business District (Phase II), PMB 425 Garki, Abuja</wicri:regionArea><wicri:noRegion>Abuja</wicri:noRegion></affiliation></author><author><name sortKey="Okuma, James" sort="Okuma, James" uniqKey="Okuma J" first="James" last="Okuma">James Okuma</name><affiliation wicri:level="1"><nlm:aff id="Aff2"><institution-wrap><institution-id institution-id-type="GRID">grid.421160.0</institution-id><institution>Department of Research,</institution><institution>Institute of Human Virology,</institution></institution-wrap>Abuja, Nigeria</nlm:aff><country xml:lang="fr">Nigeria</country><wicri:regionArea>Abuja</wicri:regionArea></affiliation></author><author><name sortKey="Leeman, Annemiek" sort="Leeman, Annemiek" uniqKey="Leeman A" first="Annemiek" last="Leeman">Annemiek Leeman</name><affiliation wicri:level="1"><nlm:aff id="Aff3"><institution-wrap><institution-id institution-id-type="GRID">grid.417770.2</institution-id><institution></institution><institution>DDL Diagnostic Laboratory,</institution></institution-wrap>Visseringlaan 25, 2288 ER Rijswijk, Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Visseringlaan 25, 2288 ER Rijswijk</wicri:regionArea><wicri:noRegion>2288 ER Rijswijk</wicri:noRegion></affiliation></author><author><name sortKey="Kasius, Annemieke" sort="Kasius, Annemieke" uniqKey="Kasius A" first="Annemieke" last="Kasius">Annemieke Kasius</name><affiliation wicri:level="1"><nlm:aff id="Aff3"><institution-wrap><institution-id institution-id-type="GRID">grid.417770.2</institution-id><institution></institution><institution>DDL Diagnostic Laboratory,</institution></institution-wrap>Visseringlaan 25, 2288 ER Rijswijk, Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Visseringlaan 25, 2288 ER Rijswijk</wicri:regionArea><wicri:noRegion>2288 ER Rijswijk</wicri:noRegion></affiliation></author><author><name sortKey="De Koning, Maurits" sort="De Koning, Maurits" uniqKey="De Koning M" first="Maurits" last="De Koning">Maurits De Koning</name><affiliation wicri:level="1"><nlm:aff id="Aff3"><institution-wrap><institution-id institution-id-type="GRID">grid.417770.2</institution-id><institution></institution><institution>DDL Diagnostic Laboratory,</institution></institution-wrap>Visseringlaan 25, 2288 ER Rijswijk, Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Visseringlaan 25, 2288 ER Rijswijk</wicri:regionArea><wicri:noRegion>2288 ER Rijswijk</wicri:noRegion></affiliation></author><author><name sortKey="Quint, Wim" sort="Quint, Wim" uniqKey="Quint W" first="Wim" last="Quint">Wim Quint</name><affiliation wicri:level="1"><nlm:aff id="Aff3"><institution-wrap><institution-id institution-id-type="GRID">grid.417770.2</institution-id><institution></institution><institution>DDL Diagnostic Laboratory,</institution></institution-wrap>Visseringlaan 25, 2288 ER Rijswijk, Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Visseringlaan 25, 2288 ER Rijswijk</wicri:regionArea><wicri:noRegion>2288 ER Rijswijk</wicri:noRegion></affiliation></author><author><name sortKey="Adebamowo, Clement" sort="Adebamowo, Clement" uniqKey="Adebamowo C" first="Clement" last="Adebamowo">Clement Adebamowo</name><affiliation wicri:level="2"><nlm:aff id="Aff4"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2175 4264</institution-id><institution-id institution-id-type="GRID">grid.411024.2</institution-id><institution>Department of Epidemiology and Public Health,</institution><institution>University of Maryland School of Medicine,</institution></institution-wrap>Baltimore, MD USA</nlm:aff><country>États-Unis</country><placeName><region type="state">Maryland</region></placeName><wicri:cityArea>Baltimore</wicri:cityArea></affiliation><affiliation wicri:level="2"><nlm:aff id="Aff5"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2175 4264</institution-id><institution-id institution-id-type="GRID">grid.411024.2</institution-id><institution>Institute of Human Virology and Greenebaum Comprehensive Cancer Centre,</institution><institution>University of Maryland School of Medicine,</institution></institution-wrap>Baltimore, MD USA</nlm:aff><country>États-Unis</country><placeName><region type="state">Maryland</region></placeName><wicri:cityArea>Baltimore</wicri:cityArea></affiliation></author></analytic><series><title level="j">Infectious Agents and Cancer</title><idno type="eISSN">1750-9378</idno><imprint><date when="2017">2017</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec><title>Background</title><p>Cervical cancer incidence and mortality rates in Sub-Saharan Africa (SSA) remain high due to several factors including low levels of uptake of cervical cancer screening. Self-collection of cervicovaginal samples for HPV DNA testing may be an effective modality that can increase uptake of cervical cancer screening in SSA and hard to reach populations in developed countries. We investigated whether self-collection of cervicovaginal samples for HPV DNA tests would be associated with increased uptake of screening compared with clinic based collection of samples. Furthermore, we compared the quality of samples collected by both approaches for use in HPV genotyping.</p></sec><sec><title>Methods</title><p>We conducted a community based randomized trial in a semi-urban district of Abuja, Nigeria with 400 women, aged 30 to 65 years randomized to either hospital-collection or self-collection of cervicovaginal samples. We compared cervical cancer screening uptake among the 2 groups and evaluated the concentration of human DNA in the samples by measuring RNase P gene levels using qPCR. High-risk HPV DNA detection and typing was done using the GP5+/6+ Luminex system.</p></sec><sec><title>Results</title><p>Most participants in the self-collection arm (93%, 185/200) submitted their samples while only 56% (113/200) of those invited to the hospital for sample collection attended and were screened during the study period (<italic>p</italic> value < 0.001). Human genomic DNA was detected in all but five (1.7%) participants, all of whom were in the self-collection arm. The prevalence of high-risk HPV in the study population was 10% with types 35, 52 and 18 being the commonest.</p></sec><sec><title>Conclusions</title><p>Our study shows that self-sampling significantly increased uptake of HPV DNA based test for cervical cancer screening in this population and the samples collected were adequate for HPV detection and genotyping. Cervical cancer screening programs that incorporate self-sampling and HPV DNA tests are feasible and may significantly improve uptake of cervical cancer screening in SSA.</p></sec></div></front><back><div1 type="bibliography"><listBibl><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Ferlay, J" uniqKey="Ferlay J">J Ferlay</name></author><author><name sortKey="Soerjomataram, I" uniqKey="Soerjomataram I">I Soerjomataram</name></author><author><name sortKey="Dikshit, R" uniqKey="Dikshit R">R Dikshit</name></author><author><name sortKey="Eser, S" uniqKey="Eser S">S Eser</name></author><author><name sortKey="Mathers, C" uniqKey="Mathers C">C Mathers</name></author><author><name sortKey="Rebelo, M" uniqKey="Rebelo M">M Rebelo</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Jedy Agba, E" uniqKey="Jedy Agba E">E Jedy-Agba</name></author><author><name sortKey="Curado, M" uniqKey="Curado M">M Curado</name></author><author><name 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sortKey="Diaz, M" uniqKey="Diaz M">M Diaz</name></author><author><name sortKey="Castellsague, X" uniqKey="Castellsague X">X Castellsague</name></author><author><name sortKey="Ferrer, E" uniqKey="Ferrer E">E Ferrer</name></author><author><name sortKey="Bosch, F" uniqKey="Bosch F">F Bosch</name></author><author><name sortKey="De Sanjose, S" uniqKey="De Sanjose S">S De Sanjose</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Tourangeau, R" uniqKey="Tourangeau R">R Tourangeau</name></author><author><name sortKey="Yan, T" uniqKey="Yan T">T Yan</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>Nigeria</li><li>Pays-Bas</li><li>États-Unis</li></country><region><li>Maryland</li></region></list><tree><country name="Nigeria"><noRegion><name sortKey="Modibbo, Fatima" sort="Modibbo, Fatima" uniqKey="Modibbo F" first="Fatima" last="Modibbo">Fatima Modibbo</name></noRegion><name sortKey="Iregbu, K C" sort="Iregbu, K C" uniqKey="Iregbu K" first="K. C." last="Iregbu">K. C. Iregbu</name><name sortKey="Okuma, James" sort="Okuma, James" uniqKey="Okuma J" first="James" last="Okuma">James Okuma</name></country><country name="Pays-Bas"><noRegion><name sortKey="Leeman, Annemiek" sort="Leeman, Annemiek" uniqKey="Leeman A" first="Annemiek" last="Leeman">Annemiek Leeman</name></noRegion><name sortKey="De Koning, Maurits" sort="De Koning, Maurits" uniqKey="De Koning M" first="Maurits" last="De Koning">Maurits De Koning</name><name sortKey="Kasius, Annemieke" sort="Kasius, Annemieke" uniqKey="Kasius A" first="Annemieke" last="Kasius">Annemieke Kasius</name><name sortKey="Quint, Wim" sort="Quint, Wim" uniqKey="Quint W" first="Wim" last="Quint">Wim Quint</name></country><country name="États-Unis"><region name="Maryland"><name sortKey="Adebamowo, Clement" sort="Adebamowo, Clement" uniqKey="Adebamowo C" first="Clement" last="Adebamowo">Clement Adebamowo</name></region><name sortKey="Adebamowo, Clement" sort="Adebamowo, Clement" uniqKey="Adebamowo C" first="Clement" last="Adebamowo">Clement Adebamowo</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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